Neuroscientists have made a major breakthrough in understanding how neurons in the cortex become polarized during migration in the developing brain. This research marks a crucial step forward in determining how the cortex develops and functions, and could lead to new treatments for neurological disorders.

The research, published in Nature Neuroscience, reveals the mechanisms that control the formation of polarized neural circuits in the developing brain. The team of scientists found that the migration of neurons to the cortex is regulated by a protein called “Lef1”. This protein helps guide the neurons to the appropriate part of the cortex and also helps them orient correctly. This is the first time a mechanism has been identified for the polarized migration of neurons in the cortex.

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source: Phys.org