Scientists have developed a new method for DNA barcoding using solid-state nanopores that is able to differentiate between correctly folded and misfolded proteins. This development has the potential to revolutionize the way we diagnose and treat diseases caused by misfolded proteins. The new method works by passing a single strand of DNA through a solid-state nanopore. When the DNA passes through the nanopore, the misfolded proteins cause the nanopore to swell, thus allowing for the detection of the misfolded proteins. This method offers a fast, cost-effective, and portable way to detect misfolded proteins, which could be a game-changer for the diagnosis and treatment of diseases.

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source: Phys.org