source: Phys.org

The transient receptor potential vanilloid (TRPV1) ion channel is a polymodal nociceptor broadly expressed in sensory neurons involved in pain sensation, thereby playing an essential role in analgesia. The outer pore domain of TRPV1 is essential for regulation of this channel by temperature, protons and other toxin peptides, so rationally engineering modulators targeting the outer pore of TRPV1 is a potential strategy for regulating pain responses. Read Full Article Here