Unlocking the Mechanisms of Protein Misfolding Linked to Diseases
Recently, researchers have uncovered a set of mechanisms that are linked to protein misfolding. Protein misfolding is an important factor in numerous diseases, including Alzheimer’s, Parkinson’s, and ALS. A team of scientists from the University of California, San Diego and Stanford University utilized data from human cell cultures and mouse models to investigate the misfolding of proteins. They identified multiple pathways that are associated with protein misfolding, including changes in gene expression and altered cell cycle progression. The researchers also discovered that many proteins involved in these pathways are shared across different diseases, suggesting that targeting these pathways could have a broad impact in treating a variety of diseases.
source: Phys.org