Leaflet formation is a key process that enables the formation of cell membranes, and now, scientists have uncovered new molecular insights into the process. Using cryo-electron microscopy (cryo-EM), researchers at the University of Washington have been able to observe, in real-time, how individual molecules interact to form a two-layered membrane.

This new research, published in Nature Communications, provides unprecedented insights into the sequential formation of leaflets that make up the cell membrane. The findings could have major implications for the development of novel treatments for diseases such as cancer, Alzheimer’s, and diabetes.

“Our research sheds light on the fundamental processes of membrane biogenesis, which are essential for life. It allows us to better understand how cells assemble their membranes, and how that process can be disrupted in disease,” said lead author Dr. Meghan Brown.

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source: Phys.org