A recent study has uncovered the mechanisms that lead to genomic instability, a key factor in the development of cancers. Genomic instability is caused by a variety of factors, including DNA damage, errors in DNA replication, and epigenetic changes. These changes lead to an increase in mutations and chromosomal rearrangements, which can in turn lead to cancer. The new study has identified three distinct pathways that can lead to genomic instability. The first pathway involves the activation of DNA damage response pathways, which can lead to excessive DNA damage and chromosomal rearrangements. The second pathway involves errors in DNA replication, which can lead to the accumulation of mutations. Finally, the third pathway involves epigenetic changes, which can lead to changes in gene expression and an increased mutation rate. The study has provided a better understanding of the mechanisms that lead to genomic instability and will help researchers develop more effective treatments for cancer.

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source: Phys.org