Uncovering Structure-Destabilizing Mutations in the BCL-2 Antiapoptotic Protein
Today, scientists have discovered a new structure-destabilizing mutation in BCL-2, an antiapoptotic protein found in humans. This mutation has the potential to open up a new avenue of research for treating cancer and other diseases. Researchers have long known that BCL-2 is important for protecting cells from apoptosis and that mutations in this protein can lead to cancer. Now, scientists have identified a particular mutation that destabilizes the structure of the protein and increases its susceptibility to proteolysis, meaning it is more easily broken down and degraded. This could provide a new way to target cancer cells, by targeting the mutated BCL-2 with drugs that cause it to be broken down faster than the normal protein. This could potentially lead to new therapies for treating cancer and other diseases.
source: Phys.org