Today, scientists have revealed the molecular mechanisms of VMAT2 inhibition, an important step in understanding the actions of drugs used to treat neurological disorders. This research could lead to new treatments for Parkinson’s disease, depression, and schizophrenia, among other neurological disorders. The findings, published in Nature Communications, provide insight into how VMAT2 inhibitors work and how they could be used to help treat these conditions. VMAT2 is a protein found in the brain and other parts of the body that plays an important role in controlling the release of neurotransmitters such as dopamine, serotonin, and norepinephrine. By inhibiting VMAT2, drugs can reduce the amount of these neurotransmitters in the brain, which can help alleviate symptoms of neurological disorders.

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source: Phys.org