A new study has revealed that ribosomal gatekeepers play a crucial role in regulating translation in eukaryotes. Ribosomes are molecular centers that are responsible for the production of proteins in cells. Researchers have now identified two ribosomal gatekeepers, Rpl26 and Rpl34, showing that they are key to controlling protein synthesis in eukaryotes.

The findings, published in Nature Communications, show how Rpl26 and Rpl34 interact to regulate translation initiation. They can block or allow ribosomes to bind to the mRNA template, thereby controlling the production of proteins. The team also discovered that these gatekeepers are essential for the proper functioning of eukaryotes. In the absence of Rpl26 and Rpl34, cells were unable to produce proteins correctly, leading to a decrease in cell growth.

These findings provide new insights into the regulation of protein production and could be useful for understanding diseases caused by protein synthesis defects.

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source: Phys.org