Recent research has shown that the nucleolus, a sub-organelle inside the cell nucleus, may play an important role in the response of cancer cells to chemotherapy. In a new study published in Nature Communications, scientists have identified a specific type of DNA known as nucleolar DNA (noDNA) that is enriched in some malignant cells and may be involved in the therapeutic response of these cells. The findings provide new insights into how cancer cells can be targeted for treatment.

Researchers have discovered that certain cancer cells have higher levels of noDNA than normal cells, and that this noDNA can influence the response to chemotherapy. The team found that noDNA is enriched in malignant cells and is associated with increased sensitivity to chemotherapy. Furthermore, they showed that when noDNA is depleted, malignant cells become more resistant to chemotherapy. These findings suggest that targeting noDNA could be a powerful strategy to improve cancer treatment.

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source: Phys.org