Unsticking the Floppy Peptide Problem: A Novel Stapling Method
A new method of “stapling” peptides together has been developed by scientists at the University of Washington, providing a solution to the problem of floppy peptides. Peptides are small molecules composed of amino acids, which make them an essential part of the human body. However, these peptides are often structurally unstable, making them difficult to work with in the lab. This new stapling method allows scientists to stabilize these peptides and make them easier to study and synthesize. The team used a specific type of amino acid, called alkyne, to attach two peptides together, forming a stable product. This will allow scientists to study peptides that would have otherwise been too unstable to work with. This could lead to many important advances in medical research.
source: Phys.org