A new mechanism for mitochondrial RNA maturation has been discovered by a team of scientists, allowing for an increased understanding of how cells are able to maintain their energy output. The team, led by researchers from the University of Maryland School of Medicine, have identified the methyltransferase enzyme Mettl8 as the main mechanism responsible for the maturation of mitochondrial transcripts. The findings, published in Nature Communications, could lead to advances in the treatment of mitochondrial diseases.

By studying Mettl8, the team was able to gain insight into the role of the enzyme in the maturation of mitochondrial transcripts. They discovered that Mettl8 is responsible for a unique process, which involves the addition of methyl groups to specific RNA molecules. This process is essential for the maturation of mitochondrial transcripts and is pivotal for the cells’ energy output. The team’s findings provide valuable insight into the complex process of mitochondrial RNA maturation and could help to develop new treatments for mitochondrial diseases.

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source: Phys.org