Today, researchers have discovered a new Polycomb repressive deubiquitinase (PR-DUB) that specifically targets H2A.K119. This protein, PR-DUB2, is the first deubiquitinase to be identified that specifically recognizes this particular lysine residue. This discovery could provide a new insight into the mechanisms of epigenetic control and gene regulation, and could be a crucial step in understanding how Polycomb-mediated gene silencing works. The findings could also have implications for understanding a wide range of diseases such as cancer, where epigenetic regulation is often disrupted.

Read Full Article Here

source: Phys.org