How Adenoviruses Use Chromatin to Efficiently Modulate Gene Expression
A new study has revealed that incoming adenoviruses are able to alter the local chromatin structure of cells in order to become more efficient at delivering their genetic material. By utilizing a novel technique, the researchers were able to observe how adenoviruses interact with the host cell’s chromatin, which is the complex of proteins and DNA in the nucleus of the cell. The findings could help to improve gene delivery protocols for a range of applications, from gene therapy to vaccine development.
The team discovered that adenoviruses were able to modify the chromatin structure of the host cells, making it easier for them to access the genetic material inside. This altered chromatin structure enabled the viruses to deliver their genetic material more efficiently, which could be beneficial for a range of applications. The researchers believe that this new information could be used to develop more effective gene delivery systems for medical and scientific uses.
source: Phys.org