Development of a versatile method to synthesize functional mRNAs with diverse 5' cap structures
Synthetic mRNAs are explored rigorously for their potential as an effective genetic vector for basic research and clinical applications. Natural mRNAs have a structure on their leading (5’) ends—called the 5’ cap—that regulates their stability and translational activity. As such, there is a tremendous effort to devise new methods to chemically modify and generate functional 5’ cap structures.
source: Phys.org