Organoids have emerged as powerful model systems for understanding the biology of tissue development and disease. In a milestone study, published in Cell, researchers from the Netherlands have demonstrated a novel combination of two powerful technologies, spatial transcriptomics and optogenetics, to create a new type of organoid with unprecedented precision.

Spatial transcriptomics is a cutting-edge technology that enables researchers to study gene expression in tissues and organoids with unprecedented precision. By combining this with optogenetics – a technique that uses light to control the activity of genes – the researchers have developed organoids that can be manipulated in an unprecedentedly precise and targeted manner. This could lead to a better understanding of the complex biological processes that occur within tissues, as well as the development of novel treatments for a range of diseases.

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source: Phys.org