For scientists seeking to understand the role of iron-sulfur clusters in proteins, a new chemoproteomic platform has emerged as a promising tool. Developed by researchers at the University of Wisconsin-Madison, the platform allows for direct measurement of iron-sulfur cluster occupancy in proteins. This provides researchers with the ability to study how these clusters are involved in a variety of biological processes, from energy production to gene expression. The platform uses a combination of chemical and proteomic techniques to accurately measure the occupancy of iron-sulfur clusters in a variety of proteins. This is an important advancement in the field, as until now, scientists had to rely on indirect methods to measure iron-sulfur cluster occupancy. The new platform offers a more direct and accurate way to measure the occupancy of iron-sulfur clusters in proteins, making it an invaluable tool for researchers studying the role of these clusters in biology.

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source: Phys.org